U.S. Immigration and Customs Enforcement has renewed its pursuit of the last two fugitive sons of imprisoned Sinaloa Cartel kingpin Joaquin “El Chapo” Guzman, posting a fresh wanted poster with a $10 million reward, Fox News reports.

The poster, released Monday, names Ivan Archivaldo Guzman Salazar and Jesus Alfredo Guzman Salazar — two of the so-called “Los Chapitos” and El Chapo’s sons with his first wife, Alejandrina Maria Salazar-Hernandez. Its blunt tagline, “Two down and two to go,” appears beside Xs drawn over the faces of their already-captured brothers, Joaquin Guzman Lopez and Ovidio Guzman Lopez.

The two men still at large are charged with conspiracy to distribute a controlled substance and operating a continuing criminal enterprise, according to the report. ICE describes both as “armed and dangerous.”

El Chapo is serving a sentence of life plus 30 years at the federal supermax prison in Florence, Colorado. After his 2016 capture, control of the Sinaloa Cartel passed to Ismael “El Mayo” Zambada; following Zambada’s arrest, leadership shifted to Guzman’s four sons. Two of them — Joaquin and Ovidio Guzman Lopez — were taken into custody under the federal “Operation Take Back America” and are reportedly cooperating with authorities. Neither has been sentenced.

In his plea agreement, Guzman Lopez admitted that he and cartel associates committed violence against law enforcement, rival traffickers and members of their own organization to protect the Sinaloa Cartel’s trafficking operations. Andrew Boutros, the U.S. Attorney for the Northern District of Illinois, framed the pursuit of El Chapo’s sons as part of a broader effort to “bring to justice drug lords and other dangerous criminals who poison the American public with illegal and harmful drugs.”

Both the Trump administration in the United States and the Sheinbaum administration in Mexico have said they are focused on dismantling the cartel’s new leadership. Fox News Digital reported that it reached out to ICE and the Department of Homeland Security for additional comment on the mission to capture the two remaining Chapitos.